Emergent BioSolutions (EBS) Q3 2024 Earnings Call Transcript

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Emergent BioSolutions (NYSE: EBS)
Q3 2024 Earnings Call
Nov 06, 2024, 5:00 p.m. ET

Contents:

• Prepared Remarks
• Questions and Answers
• Call Participants

Prepared Remarks:

Operator

Thank you for standing by. My name is Chris, and I will be your conference operator today. At this time, I would like to welcome everyone to the Q3 2024 Emergent BioSolutions Inc. earnings conference call.

All lines have been placed on mute to prevent any background noise. After the speakers' remarks, there will be a question-and-answer session. [Operator instructions] Thank you. I would now like to turn the call over to Frank Vargo, assistant treasurer.

Please go ahead.

Frank Vargo -- Assistant Treasurer

Good afternoon, everyone. Thank you for joining us today as Emergent is discussing its operational and financial results for the third quarter 2024. As is customary, today's call is open to all participants, is being recorded, and is copyrighted by Emergent BioSolutions. In addition to today's press release, a slide presentation accompanying this webcast is available to all webcast participants.

Turning to Slide 3. During today's call, Emergent may make projections and other forward-looking statements related to their business, future events, their prospects, or future performance. These forward-looking statements are based on their current intentions, beliefs, and expectations regarding future events. Any forward-looking statement speaks only as of the date of this call and except as required by law, Emergent does not undertake to update any forward-looking statements to reflect new information, events, or circumstances.

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Investors should consider this cautionary statement, as well as the risk factors identified in Emergent's periodic reports filed with the SEC when evaluating their forward-looking statements. During today's call, Emergent may also discuss certain non-GAAP financial measures that involve adjustments to GAAP figures in order to provide greater transparency regarding Emergent's operating performance. Please refer to the tables found in today's press release. Turning to Slide 4, the agenda for today's call will include Joe Papa, president and chief executive officer, who will provide an update on the company's multiyear plan progress, key product highlights, and turnaround actions.

Rich Lindahl, EVP, chief financial officer and treasurer, will speak to key achievements in the third quarter, the financial results for Q3 2024, as well as full year guidance. This will be followed by a Q&A. Finally, for the benefit of those who may be listening to the replay of this webcast, this call was held and recorded on November 6th, 2024. Since then, Emergent may have made announcements related to topics discussed during today's call.

And with that, I'd like to now turn it over to Joe Papa for opening remarks. Joe?

Joe Papa -- President and Chief Executive Officer

Hello and thank you for joining us today to discuss our third quarter results and our 2024 financial outlook. I'm joined today by Rich Lindahl, our chief financial officer. Following my opening remarks, Rich will detail our quarter three performance, as well as our full year guidance update. I will close the call with a discussion of our path forward as we continue to make significant progress on our turnaround efforts.

Then we'll open up the call for questions and answers. Earlier this year, we embarked on a multiyear plan to stabilize, turn around, and, ultimately, transform the Emergent business. Based on the great efforts of the entire Emergent team I am pleased to share that we have now completed our first phase, the stabilization phase ahead of our expectations. Emergent is now embarking on the next phase or turnaround as part of our multiyear plan to transform and strengthen our business.

I'd like to recognize all of our Emergent team members who have demonstrated their commitment to delivering against our multiyear plan to stabilize, turn around, and transform the business. This stems from our collective passion to Emergent's mission to protect, enhance, and save lives against leading public health threats around the world. We plan to continue our operational improvement initiatives and focus on driving profitable growth to create sustainable value for shareholders. Beginning on Slide 6, I will review several important updates from the third quarter, as well as the full year efforts.

First, the third quarter was another strong quarter and paired with a great first six months of 2024. We are very pleased with the results year to date. I'd like to emphasize that Emergent finished the quarter in its strongest financial position since 2021. Reflecting on our strong third quarter financial performance, we are once again raising the revised midpoint for our 2024 revenue and raising our adjusted EBITDA 2024 full year guidance.

Rich will walk us through the details. We have strengthened our balance sheet and will exceed our expectations to reduce our net debt by more than $200 million this year. We successfully refinanced our debt, closing a new credit facility agreement with Oak Hill Advisors for a term loan of $250 million and using a portion of that capital to repay all amounts of outstanding under the senior bank term loan facility. We entered into a new agreement with Wells Fargo and our ABL facility that will provide revolving loan commitments and an aggregate principal amount up to $100 million.

We continue to improve working capital driven by increases in both revenue and cost savings, and we implemented a leaner, more flexible organization by streamlining our site network, including several asset sales. From an operational standpoint, we also made great strides in the execution of our strategic priorities during the third quarter. Through our relentless commitment to combat the overdose epidemic and help save lives, as we expected, NARCAN nasal spray volumes increased year to date, and we continue to meet the increased demand of Nasal Naloxone for our customers. We received FDA approval for ACAM2000 to include the mpox expanded indication in August 2024 as the public health outbreak continues across Africa and other regions.

We secured a number of contracts for our medical countermeasures business as a result of increased clarity from the U.S. government, as well as international government's plan to procure medical countermeasure products. Also, we announced on Monday, we appointed a new head of R&D and chief medical officer, Dr. Simon Lowry, who brings decades of biotech and pharma experience to redefine Emergent scientific platform for growth.

I'm also pleased to announce that Jessica Perl has been promoted to our general counsel and corporate secretary. Both will be critical leaders on the executive management team as we move the company forward. Lastly, we made substantial progress on certain legacy compliance and legal matters, including resolving our Janssen settlement for which Emergent received a $50 million payment. Also, following a successful FDA inspection at the Canton facility, which we have now divested, but importantly, the site received NAI status.

As we continue our operations, we expect to remain well-positioned to help deliver value for our customers, patients, and shareholders, all while striving to instill the highest standards of patient safety, quality, and compliance in our work every day. I know the question of the day is how does the election impact your business? We are confident that what we do at Emergent has broad-based bipartisan support. We help governments to protect from catastrophic public health threats including opioid overdose death and biodefense. Both of these programs transcend political parties.

With that, I'll hand it over to Rich to review our financials in more detail.

Richard S. Lindahl -- Executive Vice President, Chief Financial Officer, and Treasurer

Thanks, Joe. Good afternoon, everyone. We appreciate you joining the call. As Joe has just discussed coming out of the third quarter, our significant progress against our operational and financial priorities is enabling us to transition from the stabilization phase to the turnaround phase.

Our financial foundation has been meaningfully strengthened as a result of the following positive developments, which are highlighted on Slide 8 in the earnings presentation. We completed $117 million of asset sales and received a $50 million payment from Janssen Pharmaceuticals as a result of the confidential settlement agreement. Operating cash flow through September 30th was $139 million, an improvement of approximately $377 million as compared to the same period in the prior year, and net working capital improved $98 million versus the previous quarter and $100 million as compared to the prior year. These liquidity enhancements supported the refinancing of our prior secured credit facility as we entered into a new $250 million term loan from Oak Hill Advisors extending the maturity of our debt to August 2029, and we closed a $100 million asset-backed revolving credit facility led by Wells Fargo, also maturing in 2029.

These activities resulted in the following major improvements to our credit profile. Net debt was reduced to $551 million, a $206 million reduction since the beginning of 2024. Moody's and S&P both upgraded our corporate family credit rating to B3 and B minus, respectively, with stable outlooks. And based on our improved financial position when we file our 10-Q, you will note that we have removed the prior going concern qualification.

Now shifting to key business highlights depicted on Slide 9. We received total medical countermeasure contract modifications of over $500 million this year for Anthrax MCM, smallpox MCM, and BAT, further strengthening our revenue diversification. We also announced a $42 million option exercise for continued development of the Ebanga treatment for Ebola. We are due $30 million from Bavarian Nordic as payment of the first few milestones triggered on acceptance by the EMA and FDA of the Chikungunya vaccine license applications.

NARCAN volume continues to remain strong, up 7% year to date, and its value proposition continues to drive a differentiated price point as compared to generic competition. And finally, we're further raising the midpoints of our revenue and adjusted EBITDA guidance for 2024. Turning to our financial results, we built upon our solid first half performance with continued strength in the third quarter. As indicated on Slide 10, highlights in the third quarter include total revenues of $294 million at the upper end of our guidance range and a 9% improvement year over year.

Total segment adjusted gross margin at 59%, a significant improvement both sequentially and year over year, and adjusted EBITDA of $105 million, or 36% of revenues, an improvement of $85 million versus the prior year. Diving deeper into quarterly revenues, important items on Slide 11 include NARCAN sales of $95 million, which reflects continued strong volume in our U.S. public interest channel. It's important to note that the prior year included the initial stock in volume and revenue associated with the launch of NARCAN OTC.

Price was lower year over year as a result of our previously announced price decrease in September 2023, which was announced with the over-the-counter launch. Anthrax MCM sales of $11 million, a decrease versus the prior year due to the timing of deliveries in 2024, smallpox MCM sales of $133 million, which included deliveries of the previously announced ACAM2000 and VIGIV contract options to the U.S. government, other product sales of $30 million driven by BAT, or Botulism Antitoxin Heptavalent, and total bioservices revenues of $14 million. Note that the 9% year-over-year growth in total revenues came despite the divestitures of Camden and RSDL.

This outcome reinforces the value of our revenue diversification. Transitioning to operating expenses on Slide 12. Our previously announced cost actions were fully implemented by the third quarter resulting in a significant improvement in our total operating expenses. Total adjusted gross margin was 59% in the quarter, trending to a more normalized level and directionally consistent with performance prior to the pandemic.

Adjusted gross margin performance by business segment was as follows. Commercial products was 50%, which highlights key cost reduction initiatives with our suppliers partially offsetting the lower sales price within the public interest channel. MCM products' adjusted gross margin was 73% and was influenced by higher delivery volumes, as well as reduced expenses in our manufacturing facilities. And the services segment adjusted gross profit was negative $7 million, which on a cash basis excluding depreciation is approaching breakeven.

Total research and development and SG&A improved $11 million or 11% year over year. This was driven by lower compensation due to the previously announced 2023 and 2024 restructuring initiatives, reduced internal R&D project expenses, and reduced legal fees due to the settlement of key disputes. SG&A also includes a one-time $10 million settlement charge in Q3 related to the shareholder litigation matter. So, on a normalized basis, SG&A improved $19 million versus the prior year and we expect further run rate reductions as we exit 2024 and realize the full impact of the cost actions taken to date.

Additional details on our operating expenses can be found in the appendix of the earnings deck. I will now take a moment to summarize our 2024 year-to-date performance as shown on Slide 13. Revenue was $849 million, up 10% versus the prior year driven by U.S. government and international medical countermeasures.

Year to date, adjusted gross margin was $381 million or 46% reflecting our prior efforts to reduce costs, as well as MCM sales timing. And adjusted EBITDA was $162 million, an improvement of $188 million versus the prior year. Turning to Slide 14, we'd like to highlight the significant improvements we've made to our financial metrics. At the end of the third quarter, total cash was $150 million.

This was aided by generating $139 million of operating cash, which as I said earlier, was an improvement of $377 million year over year. We also achieved a reduction of $98 million in our net working capital versus the prior quarter. The strong performance in the business coupled with our debt refinancing and reduction efforts, has lowered our net leverage to 3.3 times adjusted EBITDA a material improvement versus the third quarter of 2023. And with the fully available $100 million undrawn asset-backed revolver, total liquidity at the end of Q3 was $250 million, an increase of approximately $170 million as compared to the second quarter of 2024.

Turning to 2024 guidance, please see Slide 15. With our continued strong performance year to date, we're further raising the midpoint of our revenue and adjusted EBITDA guidance. 2024 full year guidance is as follows and the details are shown on Slide 26 in the appendix. Total revenues of $1.065 billion to $1.125 billion.

Commercial product sales of $420 million to $430 million. We continue to see strong volume demand for NARCAN and the revised guidance takes into account a balanced approach in the competitive environment. MCM product sales of $510 million to $550 million. This includes all of the previously announced contract modifications.

And at this point the vast majority of the MCM revenue is committed in 2024. Services segment revenue of $105 million to $110 million, a decrease versus the prior guidance due to the sale of our Canton facility on August 20th. Shifting to profitability metrics, we're forecasting adjusted EBITDA of $180 million to $200 million. This increase at the midpoint reflects the recently announced awards for our MCM products, as well as our continued realization of lower operating expenses.

For the full year of 2024 we're forecasting total segment adjusted gross margin of 43% to 45%. That's it for the financial update. I'll now turn the call back over to Joe.

Joe Papa -- President and Chief Executive Officer

Thank you, Rich. As we look forward, we see meaningful opportunities for Emergent's in-line products and future growth drivers that have the potential to impact lives around the world. Let me dive deeper on Slide 17 with key highlights around NARCAN Nasal Spray. While there's still a tragic number of deaths caused by an opioid, fentanyl, or heroin, recent preliminary data from the CDC points to a meaningful decline in overdose deaths in the U.S.

for the first time in decades. However, rates of overdose deaths still remain particularly high among various demographics of people and regions across the U.S. So, we must remain focused on efforts to continue broadening access, increasing awareness, and helping to maintain affordability of NARCAN Nasal Spray. To this end, demand for NARCAN, especially from public interest partners and expanded categories like business and retail channels remains on course.

We believe the NARCAN Nasal Spray value proposition continues to support a differentiated price point for a public interest of customers, and we tend to competitively price our NARCAN products. We also believe our best-in-class service, NARCANDirect, is a differentiated capability for our customers. In August, we announced a new distribution center in Nevada to further demonstrate our customer-focused approach and continued investments in NARCAN supply readiness efforts. Across Canada, we are making significant strides to increase access in British Columbia and Western Canada where take-home naloxone kits are becoming more readily available to prevent overdose deaths.

Our efforts to broaden access through OTC channels in the U.S. help encourage individuals to ensure at home, at school, at work safety plans include NARCAN. These include our continued pledge to support the White House challenge to save lives from overdose through workplace and public safety measures, our engagement with the National Safety Council and other partners to educate and reach businesses. We want to specifically acknowledge that Amazon has publicly announced their efforts to keep employees safe in the workplace.

Our continued commitment to educate through our Ready to Rescue campaign to expand awareness in NARCAN, particularly among young adults in vulnerable communities. And this month we donated 20,000 additional doses of NARCAN to organizations in need. As stated, we will remain focused on a multi-pronged strategy and effort to help save lives while relying upon strong bipartisan support to combat this tragic epidemic. Turning to our medical countermeasures portfolio on Slide 18, we are seeing tangible benefits from our product diversification and will continue to follow this approach.

This starts with maintaining our unique position to prepare and respond to public health threats through our continued engagement with U.S. government and international customers. During the third quarter, we gained FDA approval for the use of ACAM2000 to treat and prevent mpox infection, which further strengthens and broadens our smallpox portfolio. This expanded indication has enabled us to have a very important seat at the table as international leaders to help respond to the mpox outbreak.

Also in August, we proudly donated 50,000 doses of ACAM2000 for potential deployment across countries in Central Africa. As we look forward, we believe we are well-positioned to support the global response by actively engaging with world health leaders, deploying available product inventory based on the needs, and the ability to increase supply if needed. One promising medical countermeasure product with the development highlights from this quarter, we announced a $42 million contract option with BARDA to develop and scale Ebanga, a licensed treatment for Ebola. Earlier today or just recently, we announced our work to support a clinical trial sponsored by PANTHER and led by Africa CDC to evaluate the safety and efficacy of tembexa or brincidofovir in treating mpox infections across Africa.

In summary, we are proud to be a trusted partner to supply medical countermeasures for biodefense and health preparedness around the world. Turning to Slide 19, I'd like to touch on several of our turnaround phase focus areas that we will focus on and anticipate that can lead to future growth drivers. Continuing to be a mission-driven company that strives to be a leader in public health, maintaining a level of revenue diversification across our products, strategically focusing on international expansion efforts and line extensions of our current product, and creating long-term and sustainable value for our shareholders. On Slide 20, we provide a summary of our products, indications, current market, and our future growth opportunities.

On Slide 21, we outline significant progress on the strategic operational changes to stabilize our financial position. And I am excited about how we are positioned for the future as we enter a new phase of turnaround growth. Our confidence in our financial stability is based on our strong third quarter and year-to-date results, the significant reduction in our total quantum of debt, and importantly our cash generation. Our commitment to ensuring public health preparedness with NARCAN Nasal Spray in our medical countermeasure products.

And as I mentioned, with the addition of the new leadership of Dr. Lowry as our chief medical officer and head of R&D, I believe we have the right team and capabilities to accomplish our turnaround goals over the next 18 to 24 months. We are grateful to the entire Emergent team for all of their work to date and look forward to seeing what else we can accomplish together. I look forward to keeping you updated on our continued progress as we continue to transform and strengthen Emergent and enter this exciting turnaround phase for our company.

Thank you. And now, operator, I'd like to turn it back to you for a question and answer.

Questions & Answers:

Operator

We will now begin the question-and-answer session. [Operator instructions] We will pause for just a moment to compile the Q&A roster. And your first question comes from the line of Brandon Folkes with Rodman and Renshaw. Please go ahead.

Brandon Folkes -- Analyst

Thanks for taking my questions and congratulations on all the progress. Maybe just two from me. Can we just talk about the gross margin on NARCAN sort of longer term? Obviously, I think, it was at about 50% this quarter. Looks very good.

Just how do we think about that with the moving pieces on NARCAN? And then maybe -- well, I'll stop that and ask my second one afterwards.

Richard S. Lindahl -- Executive Vice President, Chief Financial Officer, and Treasurer

Sure. Hi Brandon, this is Rich. I think certainly the gross margin has responded to the price reductions that we referenced earlier on the call. I think we're starting to see some stabilization in the pricing environment.

We're also continuing to look for ways to improve the cost of goods sold there as well. So, while I hesitate to give you a specific, long-term guide on gross margin there, I think, that we're stabilizing the gross margin somewhere in the area of this level.

Brandon Folkes -- Analyst

Thanks, Rich, that's very helpful. And then maybe Joe, obviously congratulations on all the progress here. Not to get greedy, but can you just elaborate on seeking new opportunities aligned to your internal capabilities? Is that something that's high on the priority list? Is that just in the infancy of exploration at this stage? And then how should we think about bringing in additional assets in '25 and any preference there on commercial versus development stage given the additions to your team?

Joe Papa -- President and Chief Executive Officer

Sure. A lot of great comments there. Let me try to take them one by one. Certainly, we're delighted with the progress, we're delighted to look at these financial results, we're delighted to pay down the debt we've been able to pay down, and certainly the net debt coming down by approximately $200 million.

We think all that's great. As we think though, about the future and the go forward, we're very much focused on growth. And what can we do to increase the growth and where can we make the resource allocations for -- to ensure growth for the future, so that's what we're focused on. I think it's going to come both internally and through business development deals.

On the internal side, clearly, you've seen some of the comments I made today about what we're doing. Rich talked about Ebanga. Clearly, we have opportunities with Tembexa and what we're doing there with the PANTHER trial and what we're doing with working with the U.S. government and BARDA.

So, there is a lot of things we can do internally. Raxibacumab is another one that we have for anthrax. A lot of those products are ones where we think there are clear opportunities that leverage our existing infrastructure on the medical countermeasures side. On the other side, on the -- what we're doing with NARCAN, we clearly believe there is opportunities to expand with NARCAN, everything from kits that go into the business I mentioned about it last time.

We've all seen, as you go into a restaurant, the defibrillator kits that are on the wall. We think that another product will clearly be our NARCAN product to save lives. You know that clearly defibrillators cost somewhere around $1800, they save 1700 lives a year. We think we can put together a NARCAN kit that costs about $45 that could save infinitely more lives.

So, we think that's another simple example of what we're trying to do to leverage the existing capabilities we have today, now as an example. But beyond kits, there is also line extension opportunities we see that can be very beneficial, especially as we think about, unfortunately, the thousands of deaths that are occurring with college students, high school students, people that we know we can do a better job of saving those lives if only we have access to the product at the time of need. And we know that at the time of need, so often there are people there with the patient. If we can just have products available, we can save lives.

So, look to us to spend more time talking about that in terms of NARCAN, new formulations, new kits, also geographic expansion. And then of course, what I mentioned on medical countermeasures are all part of it. On the business development side, I am not talking about hundreds of millions of dollars business development opportunities, but I do think there is opportunities for us to do some business development. And we're going to look to really look to those products that fit within what we do with the first responders for the NARCAN side of the business, there is other products first responders need.

We'll look to develop products for them that they need and use our distribution capabilities to get products to them. And also, on the medical countermeasures, what else can we do to help the U.S. government and other governments around the world to help their approach to medical countermeasures? So, I think there is a lot of opportunities in front of us and we look forward to having more chances to explain those and elaborate on them in the near future.

Brandon Folkes -- Analyst

Great. Thank you very much and congrats again on all the progress.

Joe Papa -- President and Chief Executive Officer

Thank you.

Richard S. Lindahl -- Executive Vice President, Chief Financial Officer, and Treasurer

Thank you, Brandon.

Joe Papa -- President and Chief Executive Officer

Operator, our next question?

Operator

And your next question comes from the line of Jessica Fye with J.P. Morgan. Please go ahead.

Unknown speaker -- J.P. Morgan -- Analyst

Hey, this is Nick on for Jess. Thanks for taking our questions. Two-parter here on NARCAN. Can you talk a little bit more of the factors that went into lowering that NARCAN guidance? Is it driven more by lower expected volumes? Or is it more on the competitive pricing pressures? And then also could you provide an update on what the latest mix of NARCAN revs is across the public interest markets, maybe some of those ex-U.S.

revs in Canada and then OTC? And how we should expect that to evolve over time?

Joe Papa -- President and Chief Executive Officer

Sure. I'll start with the first one in terms of what we're doing at NARCAN. We're looking at a couple of factors. Number one, we're looking at the expanded volume that we are seeing with NARCAN.

I think Rich made a mention of that. We're seeing about 7% year-to-date growth in volume with NARCAN and then within public interest space where we're seeing about 14%, both of those versus last year numbers. So, we're seeing volume increase to be clear. Having said that, we've said before, and we'll say it again, that we intend to price our product competitively so that we can hold on to our volumes that we think are available to us as the market leader.

We want to make sure we're holding on to those volumes. But competitive pricing it doesn't mean we're going to match all of the other players, but we want to be in the ballpark and competitive realizing that we provide other value beyond just simply the product because of our ability to have very good distribution capabilities for NARCAN. We obviously have the brand name NARCAN. We obviously have the manufacturing capability.

So, our view is that those are all important factors that we will look at to the future. And as we think about the future beyond, the next -- this year, we certainly believe also that the amount of expenditures that are going to fund this area, the $54 billion over the next 10 years by the pharma companies that have to fund the opioid settlement is going to do a lot for expanding the volume and the awareness and the education that goes into opioid overdose. So, we do think there's a lot of opportunities to go around the table. Having said all that, I want to get to the other part of your question was what are some of the other issues that we face? And that clearly as we thought about NARCAN, we wanted to make sure that we took into account some of the initiatives that we did versus a year ago and looked at, for example, we discontinued the RX NARCAN last year.

The prescription strength that was something that caused one impact in the quarter. We also looking at sales in Canada and what's happening there and also what we are offset by some things we're seeing on the OTC sales. There's a lot of different factors going into it, but we, given, the diversity of our portfolio, we felt it was prudent at this time to look at that NARCAN number, and manage that to where we think it could be. It could be an upside too, but we want to manage to that.

I think I got the first part of the question. Is there a second part as well?

Unknown speaker -- J.P. Morgan -- Analyst

Yes, the second part was the mix between --

Richard S. Lindahl -- Executive Vice President, Chief Financial Officer, and Treasurer

But I think you kind of touched on it.

Joe Papa -- President and Chief Executive Officer

Yes. The majority of the business by far is still the PIP business, somewhere in the 70% range of the totality of the business. I think that's the question, right?

Unknown speaker -- J.P. Morgan -- Analyst

Yes. And then just to follow up there. In the PIP market, can you talk a bit more about some of the competitive dynamics you're seeing there? I mean, just thinking about any contract between competitors in states that could be unfolding kind of similar to what we saw in the state of California?

Joe Papa -- President and Chief Executive Officer

Sure. Yes. We have followed that, as you would imagine very closely and we are doing well. Clearly, there are some like in the CalRx program that the competitor did pick up that business, but across all the different states, we're doing very well.

The one thing I probably should have mentioned, I don't recall I said exactly, but we're seeing pricing stabilize in the overall NARCAN business at least one of the things we follow, as you would imagine. We follow it on a weekly basis. But from July through October 2024, the pricing has been relatively stable. So, we're not seeing anything dramatically change with the pricing environment.

And as you can tell by the amount of volume we have, we're growing in terms of volumes up 7% for the total business versus last year. So, relatively stable pricing environment. The prices, I'm sorry, the volume is going up about 7% for year-to-date numbers.

Unknown speaker -- J.P. Morgan -- Analyst

Great. And maybe if I could just squeeze one last one in on smallpox. On the $400 million of orders that you announced back in September, I believe it was, you noted $210 million. It hit through the end of that period, i.e., through end of 3Q, there is like a remaining $180 million or so more that is expected to hit over the course of maybe the next couple months or quarters.

Can you just kind of talk about how that's weighted across 4Q and say maybe early 2025? And how we should also think about that being broken down between various products?

Joe Papa -- President and Chief Executive Officer

Yes. Do you want to take it, Richard?

Richard S. Lindahl -- Executive Vice President, Chief Financial Officer, and Treasurer

Sure, yes. I mean, I would say that certainly, a portion of it is going to hit in fourth quarter. Most of will hit in 2025. But it's all baked into our guidance that we've updated.

Unknown speaker -- J.P. Morgan -- Analyst

Great. Thank you.

Joe Papa -- President and Chief Executive Officer

Thank you for your question. Operator, next question?

Operator

[Operator instructions] And your next question comes from the line of Alex Kelsey with Wells Fargo. Please go ahead.

Alex Kelsey -- Analyst

Hey, guys, thanks for taking the question here. If I can belabor the NARCAN question one more time. Of the 30-odd percent decline in Q3, are you able to bucket out how much of that was the year over year, call it headwind from the initial ramp of OTC? How much of that is pricing? And how much of that was organic declines or increase? I know you guys have referenced the year-to-date figure, but if there's any figure you can reference for the quarter, just to get a sense of how that segment has been performing sequentially, I think it'd be very helpful.

Richard S. Lindahl -- Executive Vice President, Chief Financial Officer, and Treasurer

Yeah. I think the stock in revenue from last year was in between $10 million to $15 million. It was probably around $12 million or so. The rest of it is really more overall mix and really driven by the pricing impacts.

Alex Kelsey -- Analyst

Got it. And I know you guys took pricing down back in, I think it was August of last year when the drug went OTC. It sounds like you've taken down pricing since then to be more competitive with generics. Is that a reasonable assumption?

Richard S. Lindahl -- Executive Vice President, Chief Financial Officer, and Treasurer

Yeah, we've been responding, as Joe said, to be competitive. We haven't been matching pricing, but we have remained competitive in the marketplace and that has resulted in us being, as Joe said, we've had some very good success in keeping a lot of the business that we had, even in light of some of the additional competition that's been out there.

Alex Kelsey -- Analyst

OK. Switching gears just in terms of asset sales, obviously, great job on the $200 million that you've done so far. But you still have extra warehouse, you still have Canton, you still have Rockville, you still have 400 Professional Drive, you still have Bayview. Any updates on thoughts around those properties, any progress on asset sales there, or anything else we should expect for the next 12 months whatever it is?

Joe Papa -- President and Chief Executive Officer

First, I compliment you on knowing our entire site network but --

Alex Kelsey -- Analyst

Yes, appreciate that.

Joe Papa -- President and Chief Executive Officer

That is something we are absolutely looking at that all the time. I don't want to make any specific comments about any individual sites. But to be clear, we have reduced significantly the operating expense of our business as I mentioned and as Rich mentioned. So, we are managing this to make sure that we bring down operating expense to manage it.

But we do believe we have a little bit more flexibility now in terms of some of those sites in terms of what the long-term opportunities can be with them, especially as we're thinking about other business development activities, things that we can bring within them to our portfolio for growth. So, I think we got a little bit more latitude. I mean some of them are absolutely, the sites you talked about and some of them, when you talked about some of the operational centers in terms of manufacturing sites, they could be more important to us, but we'll manage that. Others just don't have -- we don't have a need.

And we're going to certainly try to divest certain locations like potentially warehouse that we don't need. We divested one warehouse in Canton, Massachusetts as an example that was an unused warehouse. The more we can do those types of things, obviously, the better return on investment for our shareholders. So, we're going to be focused on it.

But I don't want to make any specific prognosis of when and where we'll do that.

Alex Kelsey -- Analyst

Could Bayview be used to manufacture GLP-1s?

Joe Papa -- President and Chief Executive Officer

Bayview is an extraordinary site that has been -- a significant amount has been invested in the site by Emergent and other government agencies and we think there's a lot of opportunities for that site in terms of capabilities, in terms of drug substance. But I don't want to specifically talk about any individual product, but it's a phenomenal site. I've had a chance to be in pharmaceutical business for over 35 years and I've been through probably hundreds of different sites. Bayview is unique.

It's a very significant opportunity and is everything is state of the art. So, there is really good capabilities there. We just got to find the right place to kick off some significant opportunities there. But it is a very unique site, got a lot of capability.

Alex Kelsey -- Analyst

OK. Got it. Last one if I can. If we just look to like 2025 and beyond and obviously, I understand, as well as anybody the lumpiness of the business.

And there's years where big orders come in or don't come in, but if I just start with call it the midpoint of EBITDA guide $190 million, even like CDMO gross profit year to date is still $60 million. And if that's approaching zero, I mean that's a big uplift right there. Not to ask for forward guidance or anything, but if you had to look to 2025 and beyond, given the big undertaking you guys have taken on the cost side of things and stabilize the business, like, is EBS kind of like a $225 million, $250 million EBITDA business plus looking forward? Or how do you guys think about the long-term earnings power of this business?

Joe Papa -- President and Chief Executive Officer

I think you probably expect my answer, that we're not going to make comments specifically about 2025. Having said that, I can certainly say that one of the things that we did is we took out ballpark of $130 million of operating expenses from the business. If you look at just even in the quarter, the operating expense reductions absent the impairment versus last year was $65 million just in the quarter. So, it tells you we're taking the steps to bring down the operating expense, number one.

Number two, I've got to say this so that everyone understands, we are continuing to maintain the capabilities to manufacture our products and have the ability to manufacture all of our products and have expectations that over the next several years we have the ability to make all the product, even with the reduction in the number of sites and the streamlining of our site network. So, that probably is the best way I can answer the question in terms of we've brought down operating expenses significantly, as I said, $65 million in the quarter versus a year ago. And then of course we still maintain, although the network is streamlined, we still maintain the capabilities to make all of our products.

Alex Kelsey -- Analyst

Got it. Thank you and best of luck with the balance of the year.

Joe Papa -- President and Chief Executive Officer

Thank you. Operator, next question?

Operator

And there are no questions at this time. I will now turn the call back over to Frank Vargo for closing remarks.

Joe Papa -- President and Chief Executive Officer

Hi, this is Joe Papa. I'll take the closing remarks. So, thank you again for everyone for joining us and we very much appreciate your interest in Emergent. We look forward to having a chance to talk to all of you in the near future.

Rich and I will be out talking to more investors in the very near future and look forward to having a chance to catch up with any of you. Thanks again for joining us today. Have a great day, everyone.

Operator

[Operator signoff]

Duration: 0 minutes

Call participants:

Frank Vargo -- Assistant Treasurer

Joe Papa -- President and Chief Executive Officer

Richard S. Lindahl -- Executive Vice President, Chief Financial Officer, and Treasurer

Brandon Folkes -- Analyst

Rich Lindahl -- Executive Vice President, Chief Financial Officer, and Treasurer

Unknown speaker -- J.P. Morgan -- Analyst

Alex Kelsey -- Analyst

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